Non-invasive technique helps monitor gene therapy

 作者:施钱泗     |      日期:2019-03-02 05:12:02
TREATING diseases by delivering genes to tissues in the body remains a huge challenge. But a non-invasive technique for monitoring the activity of added genes should help improve gene therapy methods. Eric Ahrens’s team at Carnegie Mellon University in Pittsburgh, Pennsylvania, used viruses to deliver a gene for a protein called ferritin to the brains of mice. Ferritin is an iron-binding protein that shows up clearly in MRI scans. After one day, MRI scans picked up a faint signal from the brain region where the virus was injected. After five days, there was a strong signal (Nature Medicine, DOI: