DNA-chopping molecule makes cells resistant to HIV

 作者:东榻燎     |      日期:2019-03-01 05:06:01
MICE have been made resistant to HIV by sabotaging a gene that makes white blood cells vulnerable to the virus. The cells can no longer make CCR5, a surface protein that the virus must attach to before it can infect the cell. Researchers at Sangamo BioSciences in Duarte, California, used a virus to sneak a molecule called a zinc-finger nuclease (ZFN) into human T-cells. The zinc-finger part is designed to bind exclusively to the DNA sequence that makes up the gene for CCR5. The nuclease part, an enzyme,